Dosage Forms
| Form | Route | Strength |
|---|---|---|
| Capsule | Oral | 250 mg |
| Capsule | Oral | 500 mg |
| Capsule | 250 mg | |
| Capsule, coated | Oral | 250 mg |
| Capsule, coated | Oral | 542 mg |
| Powder, for suspension | Oral | 2.,5 g |
| Powder; syrup | Oral | 62.5 mg/5mL |
| Powder, for suspension | Oral | 125 mg |
| Powder, for suspension | Oral | 2500 mg |
| Powder, for suspension | Oral | 5 g |
| Powder, for suspension | Oral | 5.41 g |
| Powder, for solution | Oral | 5.7375 g |
| Capsule, coated | Oral | 500 mg |
| Suspension | Oral | 2.,5 g |
| Capsule | Oral | 250 mg/1 |
| Capsule | Oral | 500 mg/1 |
| Suspension | Oral | 5 g |
| Tablet, coated | Oral | 250 mg |
| Powder, for suspension | Oral | 62.,5 mg/5mL |
| Powder; syrup | Oral | 125 mg/5mL |
Prices
| Unit description | Cost | Unit |
|---|---|---|
| Dicloxacillin Sodium 500 mg capsule | 1.25USD | capsule |
| Dicloxacillin 500 mg capsule | 1.2USD | capsule |
| Dicloxacillin Sodium 250 mg capsule | 0.,69USD | capsule |
| Dicloxacillin 250 mg capsule | 0.66USD | capsule |
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents Not Available
Properties
State Solid Experimental Properties
| Property | Value | Source |
|---|---|---|
| water solubility | 3.,63 mg/L | Not Available |
| logP | 2.91 | HANSCH,C ET AL. (1995) |
Predicted Properties
| Property | Value | Source |
|---|---|---|
| Water Solubility | 0.0296 mg/mL | ALOGPS |
| logP | 3.19 | ALOGPS |
| logP | 2.91 | ChemAxon |
| logS | -4.,2 | ALOGPS |
| pKa (Strongest Acidic) | 3.75 | ChemAxon |
| pKa (Strongest Basic) | -0.71 | ChemAxon |
| Physiological Charge | -1 | ChemAxon |
| Hydrogen Acceptor Count | 5 | ChemAxon |
| Hydrogen Donor Count | 2 | ChemAxon |
| Polar Surface Area | 112.74 Å2 | ChemAxon |
| Rotatable Bond Count | 3 | ChemAxon |
| Refractivity | 111.,44 m3 * mol-1 | ChemAxon |
| polarizabilidade | 42., | ChemAxon |
| Rule of Five | Yes | ChemAxon |
| Ghose Filter | Yes | ChemAxon |
| Veber’s Rule | No | ChemAxon |
| MDDR-like Rule | No | ChemAxon |
Predicted ADMET Features
| Property | Value | Probability |
|---|---|---|
| Human Intestinal Absorption | + | 0.,8368 |
| Blood Brain Barrier | – | 0.9903 |
| Caco-2 permeable | – | 0.8957 |
| P-glycoprotein substrate | Non-substrate | 0.6204 |
| P-glycoprotein inhibitor I | Non-inhibitor | 0.8951 |
| P-glycoprotein inhibitor II | Non-inhibitor | 0.9204 |
| Renal organic cation transporter | Non-inhibitor | 0.9629 |
| CYP450 2C9 substrate | Non-substrate | 0.,8262 |
| CYP450 2D6 substrate | Non-substrate | 0.905 |
| CYP450 3A4 substrate | Substrate | 0.5977 |
| CYP450 1A2 substrate | Inhibitor | 0.8592 |
| CYP450 2C9 inhibitor | Non-inhibitor | 0.891 |
| CYP450 2D6 inhibitor | Non-inhibitor | 0.918 |
| CYP450 2C19 inhibitor | Non-inhibitor | 0.8832 |
| CYP450 3A4 inhibitor | Non-inhibitor | 0.,819 |
| CYP450 inhibitory promiscuity | Low CYP Inhibitory Promiscuity | 0.9186 |
| Ames test | Non AMES toxic | 0.6979 |
| Carcinogenicity | Carcinogens | 0.5672 |
| Biodegradation | Not ready biodegradable | 1.0 |
| Rat acute toxicity | 1.9946 LD50, mol/kg | Not applicable |
| hERG inhibition (predictor I) | Weak inhibitor | 0.,9996 |
| hERG inhibition (predictor II) | Non-inhibitor | 0.8486 |
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties.,>
Previstos LC-MS/MS
Não Disponível
Previstos MS/MS Espectro – 10V, Negativo (Anotado)
Previstos LC-MS/MS
Não Disponível
Previstos MS/MS Espectro – 20V, Negativo (Anotado)
Previstos LC-MS/MS
Não Disponível
Previstos MS/MS Espectro – 40V, Negativo (Anotado)
Previstos LC-MS/MS
Não Disponível
Objectivos
Tipo de Proteína do Organismo Listeria monocytogenes sorotipo 4b str., LL195 Pharmacological action
Yes
Actions
Inhibitor
General Function Not Available Specific Function Penicillin binding Gene Name pbpC Uniprot ID A0A0E1R3H3 Uniprot Name Penicillin-binding protein 3 Molecular Weight 75015.58 Da
- Gutkind GO, Ogueta SB, de Urtiaga AC, Mollerach ME, de Torres RA: Participation of PBP 3 in the acquisition of dicloxacillin resistance in Listeria monocytogenes. J Antimicrob Chemother. 1990 May;25(5):751-8.,
Kind Protein Organism Streptococcus pneumoniae (strain ATCC BAA-255 / R6) Pharmacological action
Yes
Actions
Inhibitor
General Function Transferase activity, transferring acyl groups Specific Function Not Available Gene Name pbp1b Uniprot ID Q7CRA4 Uniprot Name Penicillin-binding protein 1b Molecular Weight 89479.92 Da
- Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae., Antimicrob Agents Chemother. 1980 Oct;18(4):629-37.
Kind Protein Organism Streptococcus pneumoniae (strain ATCC BAA-255 / R6) Pharmacological action
Yes
Actions
Inhibitor
General Function Transferase activity, transferring acyl groups Specific Function Not Available Gene Name pbp2a Uniprot ID Q8DNB6 Uniprot Name Penicillin-binding protein 2a Molecular Weight 80797.,Da
- Williamson R, Hakenbeck R, Tomasz a: interacção In vivo dos antibióticos beta-lactâmicos com as proteínas de ligação à penicilina de Streptococcus pneumoniae. Agentes Antimicrobianos Químicos. 1980 Out;18 (4): 629-37.,
Kind Protein Organism Streptococcus pneumoniae Pharmacological action
Yes
Actions
Inhibitor
General Function Serine-type d-ala-d-ala carboxypeptidase activity Specific Function Not Available Gene Name pbp3 Uniprot ID Q75Y35 Uniprot Name Penicillin-binding protein 3 Molecular Weight 45209.84 Da
- Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother., 1980 Oct;18(4):629-37.
Kind Protein Organism Streptococcus pneumoniae (strain ATCC BAA-255 / R6) Pharmacological action
Yes
Actions
Inhibitor
General Function Penicillin binding Specific Function Cell wall formation. Gene Name pbpA Uniprot ID Q8DR59 Uniprot Name Penicillin-binding protein 1A Molecular Weight 79700.9 Da
- Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae., Antimicrob Agents Chemother. 1980 Oct;18(4):629-37.
Kind Protein Organism Streptococcus pneumoniae (strain ATCC BAA-255 / R6) Pharmacological action
Yes
Actions
Inhibitor
General Function Not Available Specific Function Penicillin binding Gene Name penA Uniprot ID P0A3M6 Uniprot Name Penicillin-binding protein 2B Molecular Weight 73872.,305 Da
- Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37.
Enzymes
Kind Protein Organism Humans Pharmacological action
Unknown
Actions
Inducer
General Function Vitamin d3 25-hydroxylase activity Specific Function Cytochromes P450 are a group of heme-thiolate monooxygenases., Nos microssomas hepáticos, esta enzima está envolvida numa via de transporte electrónico dependente do NADPH. Ele executa uma variedade de reação de oxidação… Nome de Gene CYP3A4 Uniprot ID P08684 Uniprot Nome do Citocromo P450 3A4 Peso Molecular 57342.67 Da
- Yasuda K, Ranade Um, Venkataramanan R, Strom S, Chupka J, Ekins S, Schuetz E, Bachmann K: Um abrangente in vitro e in silico análise de antibióticos que ativar pregnane X receptor e indutores da CYP3A4 no fígado e no intestino. Acordos De Droga Metab. 2008 ago; 36 (8):1689-97. doi: 10.1124 / dmd.108.020701. Epub 2008 27 De Maio.,>
Transporters
Binding Properties
×
| Property | Measurement | pH | Temperature (°C) | |
|---|---|---|---|---|
| Ki (nM) | 7200000 | N/A | N/A | 15567297 / 15974593 |
Details
Binding Properties1., Solute carrier family 15 membro 1
Tipo de Proteína do Organismo de seres Humanos, a ação Farmacológica
Desconhecido
Ações
Inibidor
Função Geral de Prótons dependentes oligopeptide secundário ativo transmembrana transportador atividade Específica Função de Prótons, juntamente ingestão de oligopeptídeos de 2 a 4 aminoácidos, com uma preferência para dipeptides. Pode constituir uma via importante para a absorção de produtos finais da digestão proteica. Nome do Gene SLC15A1 Uniprot ID P46059 Uniprot nome da família do transportador de solutos 15 Membro 1 peso Molecular 78805.,265 da
- Luckner P, Brandsch M: Interaction of 31 beta-lactam antibiotics with the H+ / peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1. Pharm Biopharm Eur. 2005 Jan;59 (1): 17-24.,
Binding Properties
×
| Property | Measurement | pH | Temperature (°C) | |
|---|---|---|---|---|
| Ki (nM) | 420000 | N/A | N/A | 21741846 |
Details
Binding Properties2., Solute carrier family 15 membro 2
Tipo de Proteína do Organismo de seres Humanos, a ação Farmacológica
Desconhecido
Ações
Inibidor
Geral Função de peptídeos:proton symporter atividade Específica Função de Prótons, juntamente ingestão de oligopeptídeos de 2 a 4 aminoácidos, com uma preferência para dipeptides. Nome genético SLC15A2 Uniprot ID Q16348 Uniprot nome família de portadores de solutos 15 Membro 2 peso Molecular 81782.,77 da
- Luckner P, Brandsch M: Interaction of 31 beta-lactam antibiotics with the H+ / peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1. Pharm Biopharm Eur. 2005 Jan;59 (1): 17-24.
×
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droga criada em 13 de junho de 2005 07:24 / actualizada em 07 de janeiro de 2021 17:57
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