Dosage Forms
| Form | Route | Strength |
|---|---|---|
| Capsule | Oral | 250 mg |
| Capsule | Oral | 500 mg |
| Capsule | 250 mg | |
| Capsule, coated | Oral | 250 mg |
| Capsule, coated | Oral | 542 mg |
| Powder, for suspension | Oral | 2.,5 g |
| Powder; syrup | Oral | 62.5 mg/5mL |
| Powder, for suspension | Oral | 125 mg |
| Powder, for suspension | Oral | 2500 mg |
| Powder, for suspension | Oral | 5 g |
| Powder, for suspension | Oral | 5.41 g |
| Powder, for solution | Oral | 5.7375 g |
| Capsule, coated | Oral | 500 mg |
| Suspension | Oral | 2.,5 g |
| Capsule | Oral | 250 mg/1 |
| Capsule | Oral | 500 mg/1 |
| Suspension | Oral | 5 g |
| Tablet, coated | Oral | 250 mg |
| Powder, for suspension | Oral | 62.,5 mg/5mL |
| Powder; syrup | Oral | 125 mg/5mL |
Prices
| Unit description | Cost | Unit |
|---|---|---|
| Dicloxacillin Sodium 500 mg capsule | 1.25USD | capsule |
| Dicloxacillin 500 mg capsule | 1.2USD | capsule |
| Dicloxacillin Sodium 250 mg capsule | 0.,69USD | capsule |
| Dicloxacillin 250 mg capsule | 0.66USD | capsule |
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents Not Available
Properties
State Solid Experimental Properties
| Property | Value | Source |
|---|---|---|
| water solubility | 3.,63 mg/L | Not Available |
| logP | 2.91 | HANSCH,C ET AL. (1995) |
Predicted Properties
| Property | Value | Source |
|---|---|---|
| Water Solubility | 0.0296 mg/mL | ALOGPS |
| logP | 3.19 | ALOGPS |
| logP | 2.91 | ChemAxon |
| logS | -4.,2 | ALOGPS |
| pKa (Strongest Acidic) | 3.75 | ChemAxon |
| pKa (Strongest Basic) | -0.71 | ChemAxon |
| Physiological Charge | -1 | ChemAxon |
| Hydrogen Acceptor Count | 5 | ChemAxon |
| Hydrogen Donor Count | 2 | ChemAxon |
| Polar Surface Area | 112.74 Å2 | ChemAxon |
| Rotatable Bond Count | 3 | ChemAxon |
| Refractivity | 111.,44 m3·mol-1 | ChemAxon |
| Polarizabilidad | 42., | ChemAxon |
| Rule of Five | Yes | ChemAxon |
| Ghose Filter | Yes | ChemAxon |
| Veber’s Rule | No | ChemAxon |
| MDDR-like Rule | No | ChemAxon |
Predicted ADMET Features
| Property | Value | Probability |
|---|---|---|
| Human Intestinal Absorption | + | 0.,8368 |
| Blood Brain Barrier | – | 0.9903 |
| Caco-2 permeable | – | 0.8957 |
| P-glycoprotein substrate | Non-substrate | 0.6204 |
| P-glycoprotein inhibitor I | Non-inhibitor | 0.8951 |
| P-glycoprotein inhibitor II | Non-inhibitor | 0.9204 |
| Renal organic cation transporter | Non-inhibitor | 0.9629 |
| CYP450 2C9 substrate | Non-substrate | 0.,8262 |
| CYP450 2D6 substrate | Non-substrate | 0.905 |
| CYP450 3A4 substrate | Substrate | 0.5977 |
| CYP450 1A2 substrate | Inhibitor | 0.8592 |
| CYP450 2C9 inhibitor | Non-inhibitor | 0.891 |
| CYP450 2D6 inhibitor | Non-inhibitor | 0.918 |
| CYP450 2C19 inhibitor | Non-inhibitor | 0.8832 |
| CYP450 3A4 inhibitor | Non-inhibitor | 0.,819 |
| CYP450 inhibitory promiscuity | Low CYP Inhibitory Promiscuity | 0.9186 |
| Ames test | Non AMES toxic | 0.6979 |
| Carcinogenicity | Carcinogens | 0.5672 |
| Biodegradation | Not ready biodegradable | 1.0 |
| Rat acute toxicity | 1.9946 LD50, mol/kg | Not applicable |
| hERG inhibition (predictor I) | Weak inhibitor | 0.,9996 |
| hERG inhibition (predictor II) | Non-inhibitor | 0.8486 |
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties.,>
Predicción LC-MS/MS
No Disponible
Predicción de MS/MS Espectro – 10V, Negativo (Anotado)
Predicción LC-MS/MS
No Disponible
Predicción de MS/MS Espectro – 20V, Negativo (Anotado)
Predicción LC-MS/MS
No Disponible
Predicción de MS/MS Espectro – 40V, Negativo (Anotado)
Predicción LC-MS/MS
No Disponible
Objetivos
Tipo de Proteína Organismo Listeria monocytogenes serotipo 4b str., LL195 Pharmacological action
Yes
Actions
Inhibitor
General Function Not Available Specific Function Penicillin binding Gene Name pbpC Uniprot ID A0A0E1R3H3 Uniprot Name Penicillin-binding protein 3 Molecular Weight 75015.58 Da
- Gutkind GO, Ogueta SB, de Urtiaga AC, Mollerach ME, de Torres RA: Participation of PBP 3 in the acquisition of dicloxacillin resistance in Listeria monocytogenes. J Antimicrob Chemother. 1990 May;25(5):751-8.,
Kind Protein Organism Streptococcus pneumoniae (strain ATCC BAA-255 / R6) Pharmacological action
Yes
Actions
Inhibitor
General Function Transferase activity, transferring acyl groups Specific Function Not Available Gene Name pbp1b Uniprot ID Q7CRA4 Uniprot Name Penicillin-binding protein 1b Molecular Weight 89479.92 Da
- Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae., Antimicrob Agents Chemother. 1980 Oct;18(4):629-37.
Kind Protein Organism Streptococcus pneumoniae (strain ATCC BAA-255 / R6) Pharmacological action
Yes
Actions
Inhibitor
General Function Transferase activity, transferring acyl groups Specific Function Not Available Gene Name pbp2a Uniprot ID Q8DNB6 Uniprot Name Penicillin-binding protein 2a Molecular Weight 80797.,94 da
- Williamson R, Hakenbeck R, Tomasz A: in vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Agentes Antimicrob Chemother. 1980 Oct;18(4): 629-37.,
Kind Protein Organism Streptococcus pneumoniae Pharmacological action
Yes
Actions
Inhibitor
General Function Serine-type d-ala-d-ala carboxypeptidase activity Specific Function Not Available Gene Name pbp3 Uniprot ID Q75Y35 Uniprot Name Penicillin-binding protein 3 Molecular Weight 45209.84 Da
- Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother., 1980 Oct;18(4):629-37.
Kind Protein Organism Streptococcus pneumoniae (strain ATCC BAA-255 / R6) Pharmacological action
Yes
Actions
Inhibitor
General Function Penicillin binding Specific Function Cell wall formation. Gene Name pbpA Uniprot ID Q8DR59 Uniprot Name Penicillin-binding protein 1A Molecular Weight 79700.9 Da
- Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae., Antimicrob Agents Chemother. 1980 Oct;18(4):629-37.
Kind Protein Organism Streptococcus pneumoniae (strain ATCC BAA-255 / R6) Pharmacological action
Yes
Actions
Inhibitor
General Function Not Available Specific Function Penicillin binding Gene Name penA Uniprot ID P0A3M6 Uniprot Name Penicillin-binding protein 2B Molecular Weight 73872.,305 Da
- Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37.
Enzymes
Kind Protein Organism Humans Pharmacological action
Unknown
Actions
Inducer
General Function Vitamin d3 25-hydroxylase activity Specific Function Cytochromes P450 are a group of heme-thiolate monooxygenases., En los microsomas hepáticos, esta enzima está involucrada en una vía de transporte de electrones dependiente del NADPH. Realiza una variedad de reacción de oxidación… Nombre del gen CYP3A4 ID de Uniprot P08684 nombre de UniProt citocromo P450 3A4 peso Molecular 57342.67 Da
- Yasuda K, Ranade a, Venkataramanan R, Strom s, Chupka J, Ekins s, Schuetz e, Bachmann K: un análisis completo in vitro e in silico de antibióticos que activan el receptor de pregnano X e inducen CYP3A4 en hígado e intestino. Dispos De Metab De Drogas. 2008 Aug; 36(8): 1689-97. doi: 10.1124 / dmd.108.020701. Epub 2008 27 De Mayo.,>
Transporters
Binding Properties
×
| Property | Measurement | pH | Temperature (°C) | |
|---|---|---|---|---|
| Ki (nM) | 7200000 | N/A | N/A | 15567297 / 15974593 |
Details
Binding Properties1., Familia de portadores de soluto 15 miembro 1
tipo de proteína organismo humano acción farmacológica
Desconocido
acciones
inhibidor
función general oligopéptido dependiente de protones actividad secundaria activa del transportador transmembrana función específica ingesta de oligopéptidos acoplados a protones de 2 a 4 aminoácidos con preferencia por dipéptidos. Puede constituir una vía importante para la absorción de los productos finales de digestión de proteínas. Nombre del gen SLC15A1 identificación de Uniprot P46059 nombre de UniProt familia de portadores de soluto 15 miembros 1 peso Molecular 78805.,265 Da
- Luckner P, Brandsch M: interacción de 31 antibióticos betalactámicos con el simportador h + / péptido PEPT2: análisis de constantes de afinidad y comparación con PEPT1. Eur J Pharm Biopharm. 2005 Jan; 59 (1): 17-24.,
Binding Properties
×
| Property | Measurement | pH | Temperature (°C) | |
|---|---|---|---|---|
| Ki (nM) | 420000 | N/A | N/A | 21741846 |
Details
Binding Properties2., Familia de portadores de soluto 15 miembros 2
tipo de proteína organismo humano acción farmacológica
Desconocido
acciones
inhibidor
función general péptido: actividad de simportador de protones función específica ingesta de oligopéptidos acoplados a protones de 2 a 4 aminoácidos con preferencia por dipéptidos. Nombre del gen SLC15A2 identificación de UniProt Q16348 nombre de UniProt familia de portadores de soluto 15 miembros 2 peso Molecular 81782.,77 Da
- Luckner P, Brandsch M: interacción de 31 antibióticos betalactámicos con el simportador h + / péptido PEPT2: análisis de constantes de afinidad y comparación con PEPT1. Eur J Pharm Biopharm. 2005 Jan; 59 (1): 17-24.
×
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