Dosage Forms
| Form | Route | Strength |
|---|---|---|
| Capsule | Oral | 250 mg |
| Capsule | Oral | 500 mg |
| Capsule | 250 mg | |
| Capsule, coated | Oral | 250 mg |
| Capsule, coated | Oral | 542 mg |
| Powder, for suspension | Oral | 2.,5 g |
| Powder; syrup | Oral | 62.5 mg/5mL |
| Powder, for suspension | Oral | 125 mg |
| Powder, for suspension | Oral | 2500 mg |
| Powder, for suspension | Oral | 5 g |
| Powder, for suspension | Oral | 5.41 g |
| Powder, for solution | Oral | 5.7375 g |
| Capsule, coated | Oral | 500 mg |
| Suspension | Oral | 2.,5 g |
| Capsule | Oral | 250 mg/1 |
| Capsule | Oral | 500 mg/1 |
| Suspension | Oral | 5 g |
| Tablet, coated | Oral | 250 mg |
| Powder, for suspension | Oral | 62.,5 mg/5mL |
| Powder; syrup | Oral | 125 mg/5mL |
Prices
| Unit description | Cost | Unit |
|---|---|---|
| Dicloxacillin Sodium 500 mg capsule | 1.25USD | capsule |
| Dicloxacillin 500 mg capsule | 1.2USD | capsule |
| Dicloxacillin Sodium 250 mg capsule | 0.,69USD | capsule |
| Dicloxacillin 250 mg capsule | 0.66USD | capsule |
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents Not Available
Properties
State Solid Experimental Properties
| Property | Value | Source |
|---|---|---|
| water solubility | 3.,63 mg/L | Not Available |
| logP | 2.91 | HANSCH,C ET AL. (1995) |
Predicted Properties
| Property | Value | Source |
|---|---|---|
| Water Solubility | 0.0296 mg/mL | ALOGPS |
| logP | 3.19 | ALOGPS |
| logP | 2.91 | ChemAxon |
| logS | -4.,2 | ALOGPS |
| pKa (Strongest Acidic) | 3.75 | ChemAxon |
| pKa (Strongest Basic) | -0.71 | ChemAxon |
| Physiological Charge | -1 | ChemAxon |
| Hydrogen Acceptor Count | 5 | ChemAxon |
| Hydrogen Donor Count | 2 | ChemAxon |
| Polar Surface Area | 112.74 Å2 | ChemAxon |
| Rotatable Bond Count | 3 | ChemAxon |
| Refractivity | 111.,44 m3·mol-1 | ChemAxon |
| Polarizability | 42., | ChemAxon |
| Rule of Five | Yes | ChemAxon |
| Ghose Filter | Yes | ChemAxon |
| Veber’s Rule | No | ChemAxon |
| MDDR-like Rule | No | ChemAxon |
Predicted ADMET Features
| Property | Value | Probability |
|---|---|---|
| Human Intestinal Absorption | + | 0.,8368 |
| Blood Brain Barrier | – | 0.9903 |
| Caco-2 permeable | – | 0.8957 |
| P-glycoprotein substrate | Non-substrate | 0.6204 |
| P-glycoprotein inhibitor I | Non-inhibitor | 0.8951 |
| P-glycoprotein inhibitor II | Non-inhibitor | 0.9204 |
| Renal organic cation transporter | Non-inhibitor | 0.9629 |
| CYP450 2C9 substrate | Non-substrate | 0.,8262 |
| CYP450 2D6 substrate | Non-substrate | 0.905 |
| CYP450 3A4 substrate | Substrate | 0.5977 |
| CYP450 1A2 substrate | Inhibitor | 0.8592 |
| CYP450 2C9 inhibitor | Non-inhibitor | 0.891 |
| CYP450 2D6 inhibitor | Non-inhibitor | 0.918 |
| CYP450 2C19 inhibitor | Non-inhibitor | 0.8832 |
| CYP450 3A4 inhibitor | Non-inhibitor | 0.,819 |
| CYP450 inhibitory promiscuity | Low CYP Inhibitory Promiscuity | 0.9186 |
| Ames test | Non AMES toxic | 0.6979 |
| Carcinogenicity | Carcinogens | 0.5672 |
| Biodegradation | Not ready biodegradable | 1.0 |
| Rat acute toxicity | 1.9946 LD50, mol/kg | Not applicable |
| hERG inhibition (predictor I) | Weak inhibitor | 0.,9996 |
| hERG inhibition (predictor II) | Non-inhibitor | 0.8486 |
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties.,>
Ennusti LC-MS/MS –
Ei Saatavilla
Ennusti MS/MS-Spektri – 10V, Negatiivinen (Selityksineen)
Ennusti LC-MS/MS –
Ei Saatavilla
Ennusti MS/MS-Spektri – 20V, Negatiivinen (Selityksineen)
Ennusti LC-MS/MS –
Ei Saatavilla
Ennusti MS/MS-Spektri – 40V, Negatiivinen (Selityksineen)
Ennusti LC-MS/MS –
Ei Saatavilla
Tavoitteet
Sellainen Proteiinin Organismin Listeria monocytogenes-bakteerin serotyyppi 4b-str., LL195 Pharmacological action
Yes
Actions
Inhibitor
General Function Not Available Specific Function Penicillin binding Gene Name pbpC Uniprot ID A0A0E1R3H3 Uniprot Name Penicillin-binding protein 3 Molecular Weight 75015.58 Da
- Gutkind GO, Ogueta SB, de Urtiaga AC, Mollerach ME, de Torres RA: Participation of PBP 3 in the acquisition of dicloxacillin resistance in Listeria monocytogenes. J Antimicrob Chemother. 1990 May;25(5):751-8.,
Kind Protein Organism Streptococcus pneumoniae (strain ATCC BAA-255 / R6) Pharmacological action
Yes
Actions
Inhibitor
General Function Transferase activity, transferring acyl groups Specific Function Not Available Gene Name pbp1b Uniprot ID Q7CRA4 Uniprot Name Penicillin-binding protein 1b Molecular Weight 89479.92 Da
- Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae., Antimicrob Agents Chemother. 1980 Oct;18(4):629-37.
Kind Protein Organism Streptococcus pneumoniae (strain ATCC BAA-255 / R6) Pharmacological action
Yes
Actions
Inhibitor
General Function Transferase activity, transferring acyl groups Specific Function Not Available Gene Name pbp2a Uniprot ID Q8DNB6 Uniprot Name Penicillin-binding protein 2a Molecular Weight 80797.,94 Da
- Williamson R, Hakenbeck R, Tomasz A: In vivo vuorovaikutus beeta-laktaami-antibioottien kanssa penisilliiniä sitovien proteiinien Streptococcus pneumoniae. Antimikrobiaineet Kemother. 1980 lokakuu;18(4):629-37.,
Kind Protein Organism Streptococcus pneumoniae Pharmacological action
Yes
Actions
Inhibitor
General Function Serine-type d-ala-d-ala carboxypeptidase activity Specific Function Not Available Gene Name pbp3 Uniprot ID Q75Y35 Uniprot Name Penicillin-binding protein 3 Molecular Weight 45209.84 Da
- Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother., 1980 Oct;18(4):629-37.
Kind Protein Organism Streptococcus pneumoniae (strain ATCC BAA-255 / R6) Pharmacological action
Yes
Actions
Inhibitor
General Function Penicillin binding Specific Function Cell wall formation. Gene Name pbpA Uniprot ID Q8DR59 Uniprot Name Penicillin-binding protein 1A Molecular Weight 79700.9 Da
- Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae., Antimicrob Agents Chemother. 1980 Oct;18(4):629-37.
Kind Protein Organism Streptococcus pneumoniae (strain ATCC BAA-255 / R6) Pharmacological action
Yes
Actions
Inhibitor
General Function Not Available Specific Function Penicillin binding Gene Name penA Uniprot ID P0A3M6 Uniprot Name Penicillin-binding protein 2B Molecular Weight 73872.,305 Da
- Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37.
Enzymes
Kind Protein Organism Humans Pharmacological action
Unknown
Actions
Inducer
General Function Vitamin d3 25-hydroxylase activity Specific Function Cytochromes P450 are a group of heme-thiolate monooxygenases., Maksan mikrosomeissa, tämä entsyymi on mukana NADPH-dependent electron liikenteen reitti. Se suorittaa erilaisia hapettumisreaktioita… Geenin Nimi CYP3A4: n Uniprot ID P08684 Uniprot Nimi Sytokromi P450 3A4: n Molekyylipaino 57342.67 Da
- Yasuda K, Ranade A, Venkataramanan R, Strom S, Chupka J, Ekins S, Schuetz E, Bachmann K: kattava in vitro-ja in silico-analyysi antibiootteja, jotka aktivoivat pregnane X-reseptorin ja indusoivat CYP3A4-entsyymiä maksassa ja suolistossa. Huumeiden Metab Dispos. 2008 ELO;36(8):1689-97. doi: 10.1124 / dmd.108.020701. Epub 2008 27. Toukokuuta.,>
Transporters
Binding Properties
×
| Property | Measurement | pH | Temperature (°C) | |
|---|---|---|---|---|
| Ki (nM) | 7200000 | N/A | N/A | 15567297 / 15974593 |
Details
Binding Properties1., Liuenneen aineen harjoittaja perheen 15-jäsen 1
Sellainen Proteiinin Organismin Ihmiset Farmakologisen
Tuntematon
Toiminnot
Estäjä
Yleiset-Toiminto Protoni-riippuvainen oligopeptidi toissijainen aktiivinen läpäisevä transporter toimintaa Tietyn Toiminnon Protoni-yhdistettynä saanti oligopeptidejä 2 4 aminohappoja, joilla on mieltymys dipeptidit. Saattaa olla tärkeä keino proteiinimädätyksen lopputuotteiden imeytymiseen. Geenin Nimi SLC15A1 Uniprot ID P46059 Uniprot Nimi liuenneen aineen harjoittaja perheen 15-jäsen 1 Molekyylipaino 78805.,265 Da
- Luckner P, Brandsch M: Vuorovaikutus 31 beeta-laktaami-antibioottien kanssa H+/peptidi symporter PEPT2: analyysi affiniteetti vakiot ja vertailu PEPT1. Eur J Pharm Biofarm. 2005 Tammi;59 (1): 17-24.,
Binding Properties
×
| Property | Measurement | pH | Temperature (°C) | |
|---|---|---|---|---|
| Ki (nM) | 420000 | N/A | N/A | 21741846 |
Details
Binding Properties2., Liuenneen aineen harjoittaja perheen 15-jäsen 2
Sellainen Proteiinin Organismin Ihmiset Farmakologisen
Tuntematon
Toiminnot
Estäjä
Yleiset-Toiminto Peptidi:proton symporter toimintaa Tietyn Toiminnon Protoni-yhdistettynä saanti oligopeptidejä 2 4 aminohappoja, joilla on mieltymys dipeptidit. Geenin Nimi SLC15A2 Uniprot ID Q16348 Uniprot Nimi liuenneen aineen harjoittaja perheen jäsen 15 2 Molekyylipaino 81782.,77 Da
- Luckner P, Brandsch M: Vuorovaikutus 31 beeta-laktaami-antibioottien kanssa H+/peptidi symporter PEPT2: analyysi affiniteetti vakiot ja vertailu PEPT1. Eur J Pharm Biofarm. 2005 Tammi;59 (1): 17-24.
x
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Huumeiden luotu 13. kesäkuuta, 2005 07:24 / Päivitetty tammikuu 07, 2021 17:57
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