• Prescription Dispensing Service Inc.
  • Redpharm Drug
  • Sandoz
  • Southwood Pharmaceuticals
  • Teva Pharmaceutical Industries Ltd.,
  • Dosage Forms

    Form Route Strength
    Capsule Oral 250 mg
    Capsule Oral 500 mg
    Capsule 250 mg
    Capsule, coated Oral 250 mg
    Capsule, coated Oral 542 mg
    Powder, for suspension Oral 2.,5 g
    Powder; syrup Oral 62.5 mg/5mL
    Powder, for suspension Oral 125 mg
    Powder, for suspension Oral 2500 mg
    Powder, for suspension Oral 5 g
    Powder, for suspension Oral 5.41 g
    Powder, for solution Oral 5.7375 g
    Capsule, coated Oral 500 mg
    Suspension Oral 2.,5 g
    Capsule Oral 250 mg/1
    Capsule Oral 500 mg/1
    Suspension Oral 5 g
    Tablet, coated Oral 250 mg
    Powder, for suspension Oral 62.,5 mg/5mL
    Powder; syrup Oral 125 mg/5mL

    Prices

    Unit description Cost Unit
    Dicloxacillin Sodium 500 mg capsule 1.25USD capsule
    Dicloxacillin 500 mg capsule 1.2USD capsule
    Dicloxacillin Sodium 250 mg capsule 0.,69USD capsule
    Dicloxacillin 250 mg capsule 0.66USD capsule
    DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.

    Patents Not Available

    Properties

    State Solid Experimental Properties

    Property Value Source
    water solubility 3.,63 mg/L Not Available
    logP 2.91 HANSCH,C ET AL. (1995)

    Predicted Properties

    Property Value Source
    Water Solubility 0.0296 mg/mL ALOGPS
    logP 3.19 ALOGPS
    logP 2.91 ChemAxon
    logS -4.,2 ALOGPS
    pKa (Strongest Acidic) 3.75 ChemAxon
    pKa (Strongest Basic) -0.71 ChemAxon
    Physiological Charge -1 ChemAxon
    Hydrogen Acceptor Count 5 ChemAxon
    Hydrogen Donor Count 2 ChemAxon
    Polar Surface Area 112.74 Å2 ChemAxon
    Rotatable Bond Count 3 ChemAxon
    Refractivity 111.,44 m3 * mol-1 Chema .on
    polariserbarhed 42., ChemAxon
    Rule of Five Yes ChemAxon
    Ghose Filter Yes ChemAxon
    Veber’s Rule No ChemAxon
    MDDR-like Rule No ChemAxon

    Predicted ADMET Features

    Property Value Probability
    Human Intestinal Absorption + 0.,8368
    Blood Brain Barrier 0.9903
    Caco-2 permeable 0.8957
    P-glycoprotein substrate Non-substrate 0.6204
    P-glycoprotein inhibitor I Non-inhibitor 0.8951
    P-glycoprotein inhibitor II Non-inhibitor 0.9204
    Renal organic cation transporter Non-inhibitor 0.9629
    CYP450 2C9 substrate Non-substrate 0.,8262
    CYP450 2D6 substrate Non-substrate 0.905
    CYP450 3A4 substrate Substrate 0.5977
    CYP450 1A2 substrate Inhibitor 0.8592
    CYP450 2C9 inhibitor Non-inhibitor 0.891
    CYP450 2D6 inhibitor Non-inhibitor 0.918
    CYP450 2C19 inhibitor Non-inhibitor 0.8832
    CYP450 3A4 inhibitor Non-inhibitor 0.,819
    CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.9186
    Ames test Non AMES toxic 0.6979
    Carcinogenicity Carcinogens 0.5672
    Biodegradation Not ready biodegradable 1.0
    Rat acute toxicity 1.9946 LD50, mol/kg Not applicable
    hERG inhibition (predictor I) Weak inhibitor 0.,9996
    hERG inhibition (predictor II) Non-inhibitor 0.8486

    ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties.,>

    Forudsagt LC-MS/MS Ikke Tilgængelig Forudsagt MS/MS Spektrum – 10V, Negative (Kommenteret) Forudsagt LC-MS/MS Ikke Tilgængelig Forudsagt MS/MS Spektrum – 20V, Negative (Kommenteret) Forudsagt LC-MS/MS Ikke Tilgængelig Forudsagt MS/MS Spektrum – 40V, Negative (Kommenteret) Forudsagt LC-MS/MS Ikke Tilgængelig

    Mål

    Slags Protein Organisme Listeria monocytogenes serotype 4, str., LL195 Pharmacological action

    Yes

    Actions

    Inhibitor

    General Function Not Available Specific Function Penicillin binding Gene Name pbpC Uniprot ID A0A0E1R3H3 Uniprot Name Penicillin-binding protein 3 Molecular Weight 75015.58 Da

    1. Gutkind GO, Ogueta SB, de Urtiaga AC, Mollerach ME, de Torres RA: Participation of PBP 3 in the acquisition of dicloxacillin resistance in Listeria monocytogenes. J Antimicrob Chemother. 1990 May;25(5):751-8.,

    Kind Protein Organism Streptococcus pneumoniae (strain ATCC BAA-255 / R6) Pharmacological action

    Yes

    Actions

    Inhibitor

    General Function Transferase activity, transferring acyl groups Specific Function Not Available Gene Name pbp1b Uniprot ID Q7CRA4 Uniprot Name Penicillin-binding protein 1b Molecular Weight 89479.92 Da

    1. Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae., Antimicrob Agents Chemother. 1980 Oct;18(4):629-37.

    Kind Protein Organism Streptococcus pneumoniae (strain ATCC BAA-255 / R6) Pharmacological action

    Yes

    Actions

    Inhibitor

    General Function Transferase activity, transferring acyl groups Specific Function Not Available Gene Name pbp2a Uniprot ID Q8DNB6 Uniprot Name Penicillin-binding protein 2a Molecular Weight 80797.,94 da

    1. Williamilliamson R, Hakenbeck R, Tomas.A: in vivo interaktion mellem beta-lactam-antibiotika og de penicillinbindende proteiner fra Streptococcus pneumoniae. Antimicrob Agenter Chemother. 1980 okt; 18 (4): 629-37.,

    Kind Protein Organism Streptococcus pneumoniae Pharmacological action

    Yes

    Actions

    Inhibitor

    General Function Serine-type d-ala-d-ala carboxypeptidase activity Specific Function Not Available Gene Name pbp3 Uniprot ID Q75Y35 Uniprot Name Penicillin-binding protein 3 Molecular Weight 45209.84 Da

    1. Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother., 1980 Oct;18(4):629-37.

    Kind Protein Organism Streptococcus pneumoniae (strain ATCC BAA-255 / R6) Pharmacological action

    Yes

    Actions

    Inhibitor

    General Function Penicillin binding Specific Function Cell wall formation. Gene Name pbpA Uniprot ID Q8DR59 Uniprot Name Penicillin-binding protein 1A Molecular Weight 79700.9 Da

    1. Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae., Antimicrob Agents Chemother. 1980 Oct;18(4):629-37.

    Kind Protein Organism Streptococcus pneumoniae (strain ATCC BAA-255 / R6) Pharmacological action

    Yes

    Actions

    Inhibitor

    General Function Not Available Specific Function Penicillin binding Gene Name penA Uniprot ID P0A3M6 Uniprot Name Penicillin-binding protein 2B Molecular Weight 73872.,305 Da

    1. Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37.

    Enzymes

    Kind Protein Organism Humans Pharmacological action

    Unknown

    Actions

    Inducer

    General Function Vitamin d3 25-hydroxylase activity Specific Function Cytochromes P450 are a group of heme-thiolate monooxygenases., I levermikrosomer er dette en .ym involveret i en NADPH-afhængig elektrontransportvej. Det udfører en række o .idation reagere… Gen Navn CYP3A4 Uniprot-ID P08684 Uniprot Navn Cytochrom P450 3A4-Molekylær Vægt 57342.67 Da

    1. Yasuda K, Ranade En, Venkataramanan R, S Strom, Chupka J, Ekins S, Schuetz E, Bachmann K: En omfattende in vitro og in silico analyse af antibiotika for at aktivere pregnane X receptor og inducerer CYP3A4 i leveren og tarmen. Stof Metab Dispos. 2008 August;36 (8): 1689-97. doi: 10.1124/dmd.108.020701. Epub 2008 27 Maj.,>

    Transporters

    Binding Properties

    ×

    Property Measurement pH Temperature (°C)
    Ki (nM) 7200000 N/A N/A 15567297 / 15974593

    Details

    Binding Properties1., Opløst stof carrier familien 15-1

    Slags Protein Organisme Mennesker Farmakologiske indsats

    Ukendt

    Handlinger

    – Hæmmer

    Generelle Funktion Proton-afhængige oligopeptide sekundær aktiv transmembrane transporter aktivitet Bestemt Funktion Proton-kombineret indtagelse af oligopeptides af 2 til 4 aminosyrer med en præference for dipeptides. Kan udgøre en vigtig vej til absorption af slutprodukter til proteinfordøjelse. Gene navn SLC15A1 Uniprot ID P46059 Uniprot navn opløst carrier familie 15 medlem 1 molekylvægt 78805.,265 Da

    1. Luckner S, Brandsch M: Samspillet mellem 31 beta-lactam antibiotika med H+/peptid-symporter PEPT2: analyse af affinitet konstanter og sammenligning med PEPT1. Eur J Pharm Biopharm. 2005 Jan;59 (1): 17-24.,

    Binding Properties

    ×

    Property Measurement pH Temperature (°C)
    Ki (nM) 420000 N/A N/A 21741846

    Details

    Binding Properties2., Opløst stof carrier familien 15-2

    Slags Protein Organisme Mennesker Farmakologiske indsats

    Ukendt

    Handlinger

    – Hæmmer

    Generelle Funktion Peptid:proton-symporter aktivitet Bestemt Funktion Proton-kombineret indtagelse af oligopeptides af 2 til 4 aminosyrer med en præference for dipeptides. Gene navn SLC15A2 Uniprot ID1616348 Uniprot navn opløst carrier familie 15 medlem 2 molekylvægt 81782.,77 Da

    1. Luckner S, Brandsch M: Samspillet mellem 31 beta-lactam antibiotika med H+/peptid-symporter PEPT2: analyse af affinitet konstanter og sammenligning med PEPT1. Eur J Pharm Biopharm. 2005 Jan;59 (1): 17-24.

    x

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    Drug oprettet den 13 juni 2005 07:24 / Opdateret den 07 januar, 2021 17:57